Endocrine Abstracts

Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH...

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

Traumatic brain injury (TBI) often results in long-term pituitary insufficiency. Regular endocrine screening of TBI patients is advised after the acute phase of the treatment period. We monitored pituitary functions in 32 TBI patients (28 men, 4 women). Endocrine tests were performed from 3 to 36 months after the brain injury. Thyroid functions, cortisol and ACTH levels, prolactin, sex hormone concentrations, GH/IGF1 axis and posterior pituitary function were evaluated. Additi...

Drug-induced vasculitis or lupus-like syndromes can complicate the clinical course of PTU-treated patients. The clinical manifestations of four patients treated with PTU for Graves’ disease are presented.A 37-year-old woman was treated with PTU for six years. She had severe thyrotoxicosis, high fever and polyarthralgia. Elevated doses of PTU resulted in normalization of thyroid function, but the fever and arthralgia persisted even after steroid admi...

Objective: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of post-radioiodine therapy SPECT/CT of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis.Patients and Methods: 323 consecutive patients, 181 at the University of Pecs and 142 at the University of Debrecen, were investigated after their first radioiodine treat...